• IDA Research Guide Overview
  • Locating your targets.
  • Obtaining medical school catalogs.
  • Using the World Wide Web to find information.
  • Obtaining CRISP Abstracts.
  • Using the Gopher system.
  • The Department of Defense web site.
  • Freedom of Information Act requests.
  • Obtaining USDA Annual reports.
  • Obtaining USDA Inspection reports.
  • Investigating your targets with Medline.
  • Medline on the World Wide Web.
  • Contacting the National Institute of Health.
  • Other important documents.
  • Reviewing journal articals, grants and other documents.
  • Obtaining professional opinions.
  • Writing a brochure or fact sheet.
  • Regulatory and animal care guides.
  • Attending IACUC meetings.
  • Conclusion.

    Research guide resources:

  • Organizations.
  • Common NIH Grant Designations.
  • Sample CRISP Abstract and Indexing Terms.
  • Sample DOD Abstract
  • Sample FOIA letter.
  • Sample Necropsy Report.







    		• Sample DOD Abstract

    Title: Investigate and Define Mechanisms of Nerve Agent Induced Convulsions

    FY95 Funding: $185,000

    Primary Contact:
    Public Affairs Office
    Organization: Walter Reed Army Institute of Research
    Address: MCMR-UWZ-I
    City: Washington
    State: DC
    Zip: 20307-5100

    Performing Organization:
    Walter Reed Army Institute of Research
    Address:
    City: Washington
    State: DC
    Zip: 20307-5100

    Objective and Approach:
    Develop an anticonvulsant that can be used to pretreat or treat soldiersexposed to chemical warfare agents so that agent produced seizures are prevented.Test potential anticonvulsants for adverse neurobehavioral side effectsin animals using a variety of tasks suitable for animal-to-man extrapolation.

    Test potential anticonvulsants in whole animal models of seizure activity(NMDA, flurothyl and electrically stimulated seizures) for efficacy andin neuronal cell culture for mechanism of action information. Test behavioraleffects of potential anticonvulsants in animal models of performance.
    Synthesis of novel bimodal prodrugs that are carbamate and anticholinergics;specifically bifunctional carbamates with aprophen substitutes will be synthesized.Animal models will be developed and carbaphens will be tested. Packagingof carbaphens for storage and stability and delivery will be examined.

    Indexing Terms:
    lab animals
    rats
    primates
    anticonvulsants
    dextromethorphan
    carbetapentane
    pharma cological
    protection
    behavioral side effects
    cognitive performance
    NMDA
    antagonists
    memory
    decision
    making
    vigilance
    carbaphens
    bin ary antidotes
    organophosphates

    Research was conducted in compliance with the Animal Welfare Act and other Federal statutes and regulations relating to the use of animals inresearch and was reviewed and approved by the Institute's Animal Care andUse Committee.