• IDA Research Guide Overview
  • Locating your targets.
  • Obtaining medical school catalogs.
  • Using the World Wide Web to find information.
  • Obtaining CRISP Abstracts.
  • Using the Gopher system.
  • The Department of Defense web site.
  • Freedom of Information Act requests.
  • Obtaining USDA Annual reports.
  • Obtaining USDA Inspection reports.
  • Investigating your targets with Medline.
  • Medline on the World Wide Web.
  • Contacting the National Institute of Health.
  • Other important documents.
  • Reviewing journal articals, grants and other documents.
  • Obtaining professional opinions.
  • Writing a brochure or fact sheet.
  • Regulatory and animal care guides.
  • Attending IACUC meetings.
  • Conclusion.

    Research guide resources:

  • Organizations.
  • Common NIH Grant Designations.
  • Sample CRISP Abstract and Indexing Terms.
  • Sample DOD Abstract
  • Sample FOIA letter.
  • Sample Necropsy Report.

  • Sample Necropsy Report

    Pathology Report
    Path No.: n/a
    ID No. CA1376
    Sex: Male
    Species: Chimpanzee
    Date of Death: 29 July 1994
    Pathologists: Robert Eason, DVM and Gary Sibert, DVM, Ph.D.


    Dr. Frost called Dr. Eason approximately 10:30 a.m. 29 July 1994 with messagethat a chimpanzee was found dead and that it "appeared like bloat,the abdomen was reddish purple."

    No additional clinical data was provided with the animal.

    The animal was taken from the 40 degree F morgue where it was placed onthe necropsy table at approximately 1:30 p.m. July 29, 1994.

    The tatoo on the animal's inner right thigh was 1376.

    The animal was a young adult male in good body flesh and hair coat. Theanimal was in rigor mortis. The mucous membranes of the mouth were a darkpurple color (cyanotic). No oral lesions were present. The lower abdomenhad liver mortis suggesting ventral recumbency post mortem. The skeletonappeared normal except for an occipital bone asymmetry. No signs of traumawere found externally.

    A standard "Y" incision was made and the subcutaneous were examinedand no lesions were found. The abdominal and thoracic viscera were examinedand the stomach contained watery contents with no solid ingesta. The gastricmucosa and valves appeared normal. The entire digestive tract was examinedand no lesions were found. The urinary bladder contained approximately 150ml of clear urine. The kidneys and urinary tract appeared normal. The adrenals,pancreas, spleen, and other abdominal tissues appeared normal.

    The heart had multiple petechial hemorrhages on the epicardium especiallythe right ventricle. No other abnormalities were seen in the heart or associatedgreat vessels.

    The lungs did not collapse completely and diffuse red hepatization was inall lobes. The bronchial tree had thick cloudy (purulent exudate) tenaciousfluid filling the lumens. Similar exudate was adhered to the lower trachealwall. The structures of the oral cavity and pharynx appeared normal.

    The cranial cavity was opened and the meninges over the entire brain wascloudy with a purulent exudate. The meninges of the spinal cord had a similarappearance.

    Bacterial cultures were taken of the meninges and bronchi. Samples representativeof all organ systems were collected in buffered formalin.

    Gross Diagnoses:

    Pneumonia, acute, suppurative, diffuse, all lobes of the lung, etiology_Streptococcus pneumoniae_.

    Meningitis, suppurative, diffuse, meninges of brain and spinal cord, etiology_Streptococcus pneumoniae_.


    The presence of suppurative meningitis with pneumonia is most commonly causedby pyogenic bacteria but can also be caused by mycoplasma and other lesscommon organisms. Samples of brain was frozen at -70 C for additional etiologicstudy if the bacterial cultures and histological examination of collectedtissues do not result in isolation and identification of a probable pathogen.Sensitivity tests were also ordered of any isolated pathogens.


    _Streptococcus pneumoniae_ subsequently isolated from the bronchus and brainand had identical antibiotic sensitivity profiles suggesting with high probabilitythat the animal had a primary pneumonia that extended to meninges.

    Robert Eason, DVM, Gary Sibert, DVM, Ph.D.